Tag: G-coupled protein receptor



Cannabidiol to get High; a Non-psychoactive

Cannabidiol (CBD)—a non-psychoactive, non-toxic, non-addictive, and safe compound that can help treat various health issues. The cannabis plant contains different cannabinoids, and CBD and THC are two of the most recognizable ones. After consuming THC, consumers typically feel psychoactive effects or a “high” feeling. Whereas, after consuming CBD, consumers experience different medical and therapeutic benefits without the high. Why is this though, and can you consume cannabidiol to get high? Or, is this compound for just its variety of health benefits and physically calming effects?

Differences Between CBD and THC

Overall, CBD and THC are vastly different cannabinoids that can each help consumers. These compounds can also deliver different medical, therapeutic, and nutritional benefits. However, THC is often for recreational purposes like getting high. Whereas, CBD is mostly for medical purposes and to experience quality of life and/or well-being improvements. Since THC is known to deliver psychoactive effects, this cannabinoid is not particularly suitable for children, teenagers, and some elderly people.

However, CBD is suitable for people of all ages. It is especially useful for those who do not respond to other medications. Although CBD and THC are both beneficial, nowadays, CBD is consumed by more people worldwide. This is because numerous U.S. states and countries prohibit the growing, selling, and consumption of THC products. Oppositely, due to CBD’s non-psychoactive and non-toxic make-up, numerous geographic locations have legalized it.

Getting High from THC, and Not From CBD

To experience psychoactive effects, consuming Cannabidiol to get high is not the way to go. CBD can help alleviate various symptoms, improve your well-being, and help treat different ailments. However, consuming this compound will not deliver psychoactive results. Instead, you will likely experience physically relaxing effects from CBD. You may wonder why consuming Cannabidiol to get high is not possible. What are the reasons behind this?

In addition, each cannabinoid binds to different receptors within our bodies. The two main receptors are known as CB1 and CB2. THC activates and binds to the CB1 receptor. This receptor is heavily concentrated in the central nervous system. THC can also bind to the body’s CB2 receptors. This receptor is concentrated in various peripheral tissues and the immune system. When THC binds to CB1 receptors in our brain, our natural reward system activates. This plays a significant role in THC’s capability to generate euphoria and a “high” feeling.

Which Receptors CBD Binds To

Whereas, CBD struggles to bind to the CB1 and CB2 receptors. Instead, the cannabinoid does not possess a specific binding affinity like THC does. However, CBD interacts with different non-cannabinoid receptors and ion channels including the following:

Anandamide, adenosine, PPARs (peroxisome proliferator activated receptors), G-coupled protein receptor, serotonin, and vanilloid receptors

CBD binds to these receptors to generate and deliver therapeutic and medical benefits. These non-cannabinoid receptors and ion channels are also recognized for their ability to facilitate different functions. Some of these functions include inflammation, pain perception, mood, addiction, appetite, and sleep. Due to CBD’s inability to bind to CB1 and CB2 receptors, consuming Cannabidiol to get high will not happen.

Therefore, to experience more than just medical benefits, using Cannabidiol to get high is not an option. To feel psychoactive effects though, THC should be consumed instead. Nonetheless, CBD and THC are both useful cannabinoids that can significantly help you. Which cannabinoid do you prefer consuming, and why?